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Whereas GS themselves are not significant chemoprotectors, they are converted by coexisting plant myrosinases and the gastrointestinal microflora of humans to ITCs, which are. Plant-based diets rich in crucifers are effective in preventing cancer and other chronic diseases. Crucifers contain very high concentrations of glucosinolates (GS; -thioglucoside-N. Plant-based diets rich in crucifers are effective in preventing cancer and other chronic diseases. Crucifers contain very high concentrations of glucosinolates (GS; -thioglucoside-N. ABSTRACT: Broccoli sprout (BS) supplements have been marketed for over a decade for the promising health beneficial effects of sulforaphane (SFN), which induces Nrf2 signaling and downstream.